前药
过氧化氢酶
过氧化氢
线粒体
生物相容性
化学
活性氧
共价键
组合化学
谷胱甘肽
激进的
细胞内
药物输送
癌症治疗
癌细胞
过氧化物
癌症治疗
羟基自由基
生物物理学
硫醇
细胞器
生物正交化学
二硫键
生物化学
超氧化物歧化酶
酶
药理学
硝基还原酶
胞浆
氧化应激
立体化学
硫分解
劈理(地质)
作用机理
生物转化
癌症
作者
Qihang Ding,Bo Wang,Zixuan Zhan,Paramesh Jangili,Junyang Chen,Rakesh Mengji,Hyeonji Rha,Li Yang,Jian Tian,Jong Seung Kim
出处
期刊:Angewandte Chemie
[Wiley]
日期:2025-09-09
卷期号:64 (44): e202509183-e202509183
被引量:12
标识
DOI:10.1002/anie.202509183
摘要
), offers a promising cancer treatment strategy due to its high specificity and low systemic toxicity. However, the targeted delivery of •OH-producing prodrugs using covalent organic frameworks (COFs) remains a significant challenge. Here, we report a mitochondria-targeted COF-based nano prodrug, COF-31@P, designed for enhanced CDT efficacy. COF-31@P is composed of a Fenton-like copper complex and the hydrogen peroxide enzyme inhibitor 3-amino-1,2,4-triazole (3-AT), linked via disulfide bonds that are selectively cleaved by tumor-specific glutathione (GSH). This cleavage triggers the release of active components, resulting in robust •OH generation and effective eradication of cancer cells. The platform demonstrates precise mitochondrial targeting, high therapeutic efficiency, and excellent biocompatibility in vivo. By combining organelle targeting and multi-synergistic •OH generation production, our COF-31@P represents a significant advancement in CDT and holds strong potential for clinical translation.
科研通智能强力驱动
Strongly Powered by AbleSci AI