化学
药代动力学
残留物（化学）
体内
药理学
EC50型
效力
人类免疫缺陷病毒（HIV）
药品
组合化学
立体化学
生物化学
体外
病毒学
医学
生物
生物技术
作者
Yanying Sun,Zhenzhen Zhou,Na Wang,Fabao Zhao,Ying Liu,Xiaoxuan Xu,Xiaohan Wang,Zhenbang Gou,Erik De Clercq,Christophe Pannecouque,Peng Zhan,Dongwei Kang,Xinyong Liu
标识
DOI：10.1021/acs.jmedchem.4c00026
摘要
NNRTI is an important component of the highly active antiretroviral therapy (HAART), but the rapid emergence of drug resistance and poor pharmacokinetics limited their clinical application. Herein, a series of novel aryl triazolone dihydropyridines (ATDPs) were designed by structure-guided design with the aim of improving drug resistance profiles and pharmacokinetic profiles. Compound
科研通智能强力驱动
Strongly Powered by AbleSci AI
剑指东方是为谁
猪猪hero
chenjzhuc
斯寜
MchemG
有人
Billy
LMNg6n
若雨凌风
竹筏过海
shinysparrow
可千万不要躺平呀
stife32
bc
孤独尔白
cyanpomelo
WDS
努力羊羊
疯狂的羊癫疯
Xiaoxiao
皖公网安备34019202002308
