纳米机器人学
趋化性
药物输送
化学
癌症研究
翻译(生物学)
靶向给药
生物
细胞生物学
纳米医学
旁观者效应
脂质体
布朗运动
渗透(战争)
纳米技术
细胞
放射治疗
肿瘤细胞
免疫学
药品
癌细胞
医学
癌症治疗
作者
Zili Yang,Ziye Pei,Zhixue Gao,Ming Luo,Xingchi Liu,Jie Guo,Hao Jiang,Mengting Lv,Zi‐Li Yu,Suling Zhao,Jianguo Guan
摘要
Low tumor-targeting delivery efficiency (Ɛ) and poor tumor penetration remain critical issues in the clinical translation of nanoparticle-based drug delivery systems. Here we report that bienzyme-powered Janus nanorobots with catalase and urease covering the same hemispheres in sequence, demonstrate chemical propulsion far exceeding translational Brownian forces and torques comparable to rotational Brownian torques by leveraging endogenous urea and H₂O₂ gradient in the tumor microenvironment, showcasing ultrasensitive chemotaxis toward biomarkers over-expressed by tumor tissues centimeters away and augmented Ɛ. After intravenous injection into a tumor-bearing mouse model, the nanorobots demonstrate significant enhancement in Ɛ, penetration depth, and cell internalization, surpassing those of passive counterparts by 209, >10, and 1970 times, respectively. When loaded with antitumor drugs, they boost tumor suppression efficacy by ∼49 times compared with passive counterparts. This work offers a new strategy for next-generation drug delivery, promising a paradigm shift for self-propelled nanorobots in precision medicine.
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