体内
背景(考古学)
体内分布
中子俘获
硼
胶束
化学
医学物理学
医学
有机化学
生物
生物技术
古生物学
水溶液
作者
Tainah Dorina Marforio,Andrea Carboni,Matteo Calvaresi
出处
期刊:Cancers
[MDPI AG]
日期:2023-10-11
卷期号:15 (20): 4944-4944
被引量:1
标识
DOI:10.3390/cancers15204944
摘要
Carboranes have emerged as one of the most promising boron agents in boron neutron capture therapy (BNCT). In this context, in vivo studies are particularly relevant, since they provide qualitative and quantitative information about the biodistribution of these molecules, which is of the utmost importance to determine the efficacy of BNCT, defining their localization and (bio)accumulation, as well as their pharmacokinetics and pharmacodynamics. First, we gathered a detailed list of the carboranes used for in vivo studies, considering the synthesis of carborane derivatives or the use of delivery system such as liposomes, micelles and nanoparticles. Then, the formulation employed and the cancer model used in each of these studies were identified. Finally, we examined the analytical aspects concerning carborane detection, identifying the main methodologies applied in the literature for ex vivo and in vivo analysis. The present work aims to identify the current strengths and weakness of the use of carboranes in BNCT, establishing the bottlenecks and the best strategies for future applications.
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