再生(生物学)
生物材料
骨免疫学
骨愈合
免疫系统
巨噬细胞
骨组织
再生医学
自愈水凝胶
组织工程
细胞生物学
医学
生物医学工程
干细胞
免疫学
化学
生物
解剖
兰克尔
体外
激活剂(遗传学)
内科学
受体
有机化学
生物化学
作者
Mei Fu,Chensong Yang,Guixin Sun
标识
DOI:10.1016/j.molimm.2023.09.010
摘要
There is a high incidence of fractures in clinical practice and therapy. The repairment of critical size defects in the skeletal system remains a huge challenge for surgeons and researchers, which can be overcame by the application of bone tissue-engineered biomaterials. An increasing number of investigations have revealed that the immune system plays a vital role in the repair of bone defects, especially macrophages, which can modulate the integration of biomaterials and bone regeneration in multiple ways. Therefore, it has become increasingly important in regenerative medicine to regulate macrophage polarization to prevent inflammation caused by biomaterial implantation. Recent studies have stressed the importance of hydrogel-based modifications and the incorporation of various cellular and molecular signals for regulating immune responses to promote bone tissue regeneration and integrate biomaterials. In this review, we first elaborate briefly on the described the general physiological mechanism and process of bone tissue regeneration. Then, we summarized the immunomodulatory role macrophages play in bone repair. In addition, the role of hydrogel-based immune modification targeting macrophage modulation in accelerating and enhancing bone tissue regeneration was also discussed. Finally, we highlighted future directions and research strategies related to hydrogel optimization for the regulation of the immune response during bone regeneration and healing.
科研通智能强力驱动
Strongly Powered by AbleSci AI