Ni-Catalyzed Asymmetric C–P Cross-Coupling Reaction for the Synthesis of Chiral Heterocyclic Phosphine Oxides

Nickel performs excellently in C–C and C–X cross-coupling reactions. Here, we disclose a Ni(II)-catalyzed asymmetric C–P cross-coupling reaction to afford valuable chiral heterocyclic tertiary phosphine oxides. The method is mild and efficient, which invokes a self-sustained nickel catalytic cycle without an external reductant, light irradiation, or electricity.