纳米载体
药品
抗药性
多重耐药
脂质体
癌细胞
癌症
细胞质
药物输送
常用化疗药物
药理学
毒品携带者
靶向给药
癌症研究
医学
纳米技术
化学
生物
材料科学
生物化学
内科学
微生物学
作者
Mohsen Safaei,Fatemeh Khalighi,Fatemeh Akhavan Behabadi,Zahra Abpeikar,Arash Goodarzi,Seyed Amin Kouhpayeh,Sohrab Najafipour,Vahid Ramezani
出处
期刊:Nanomedicine
日期:2023-11-15
标识
DOI:10.2217/nnm-2023-0176
摘要
This review discusses the application of nanoliposomes containing siRNA/drug to overcome multidrug resistance for all types of cancer treatments. As drug resistance-associated factors are overexpressed in many cancer cell types, pumping chemotherapy drugs out of the cytoplasm leads to an inadequate therapeutic response. The siRNA/drug-loaded nanoliposomes are a promising approach to treating multidrug-resistant cancer, as they can effectively transmit a small-molecule drug into the target cytoplasm, ensuring that the drug binds efficiently. Moreover, nanoliposome-based therapeutics with advances in nanotechnology can effectively deliver siRNA to cancer cells. Overall, nanoliposomes have the potential to effectively deliver siRNA and small-molecule drugs in a targeted manner and are thus a promising tool for the treatment of cancer and other diseases.
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