细菌粘附素
生物
粘蛋白
粘液
微生物学
聚糖
细胞生物学
某种肠道细菌
斑马鱼
细菌
寄主(生物学)
伞
糖蛋白
毒力
遗传学
基因
生物化学
生态学
作者
T. Jarrod Smith,Deepika Sundarraman,Ellie Melançon,Laura Desban,Raghuveer Parthasarathy,Karen Guillemin
标识
DOI:10.1016/j.chom.2023.07.003
摘要
In a healthy gut, microbes are often aggregated with host mucus, yet the molecular basis for this organization and its impact on intestinal health are unclear. Mucus is a viscous physical barrier separating resident microbes from epithelia, but it also provides glycan cues that regulate microbial behaviors. Here, we describe a mucin-sensing pathway in an Aeromonas symbiont of zebrafish, Aer01. In response to the mucin-associated glycan N-acetylglucosamine, a sensor kinase regulates the expression of an aggregation-promoting adhesin we named MbpA. Upon MbpA disruption, Aer01 colonizes to normal levels but is largely planktonic and more pro-inflammatory. Increasing cell surface MbpA rescues these traits. MbpA-like adhesins are common in human-associated bacteria, and the expression of an Akkermansia muciniphila MbpA-like adhesin in MbpA-deficient Aer01 restores lumenal aggregation and reverses its pro-inflammatory character. Our work demonstrates how resident bacteria use mucin glycans to modulate behaviors congruent with host health.
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