β-Diketones, also known as 1,3-diketones, hold significant importance in synthetic organic chemistry. This review aims to provide a comprehensive overview of the seven different methods used to prepare 1,3-diketones. and these methods have been described by several researchers. In addition, β-Diketone derivatives have unique physical and chemical properties, as they exist in different tautomeric chemical forms. The most prominent derivatives of 1,3-diketones are highlighted, and the focus is on their diverse applications in various fields.