Transperineal Versus Transrectal Magnetic Resonance Imaging–targeted Prostate Biopsy: A Systematic Review and Meta-analysis of Prospective Studies

There were no significant differences in the prostate biopsy approaches (transperineal [TP] vs transrectal [TR]) for prostate cancer detection and complications. However, the MRI-targeted TP prostate biopsy approach may be advantageous as it can be performed safely without antibiotics, potentially reducing antibiotic resistance.