衣壳
药代动力学
病毒学
药理学
药物代谢
药品
候选药物
乙型肝炎病毒
病毒
新陈代谢
化学
医学
生物
生物化学
作者
Ming Li,Xingguo Yan,Li Zhang,Xinchang Liu,Yayi Liu,Qian Wang,Jing Li
出处
期刊:Xenobiotica
[Taylor & Francis]
日期:2024-07-26
卷期号:54 (9): 701-710
标识
DOI:10.1080/00498254.2024.2381223
摘要
Pibothiadine (PBD; HEC121120) is a novel hepatitis B virus capsid assembly modulator based on GLS4 (morphothiadine) and has inhibitory activities against resistant strains.To assess the overall preclinical drug metabolism and pharmacokinetics (DMPK) properties of PBD,
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