Chiral Phosphoric Acid-Catalyzed Enantioselective Synthesis of Biphenyl-Bridged ɛ-Sultams via Friedel-Crafts Reactions of Cyclic N-Sulfonylimines with Indolizines

An asymmetric aza-Friedel–Crafts arylation of biphenyl-bridged seven-membered cyclic N -sulfonylimines with indolizines via chiral phosphoric acid is realized, affording chiral indolizine modified ε-sultams with up to 99% yield and 99% ee.