吞咽不足
瘦素
内科学
内分泌学
下丘脑
后脑
外围设备
车站3
STAT蛋白
医学
化学
生物
中枢神经系统
肥胖
信号转导
生物化学
出处
期刊:American Journal of Physiology-endocrinology and Metabolism
[American Physiological Society]
日期:2023-07-01
卷期号:325 (1): E72-E82
标识
DOI:10.1152/ajpendo.00083.2023
摘要
Low-dose, chronic peripheral infusions of leptin produced an initial, transient inhibition of food intake that correlated with signal transducer and activator of transcription 3 (STAT3) activation in the ventromedial hypothalamus (VMH) and nucleus of the solitary tract (NTS). When intake normalized, but weight remained suppressed, the NTS was the only area that remained activated. These data suggest that leptin’s primary function is to reduce body fat, that hypophagia is a means of achieving this and that different areas of the brain are responsible for the progressive response.
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