医学
转化研究
重症监护医学
肝损伤
临床研究
临床实习
药品
药物开发
鉴定(生物学)
肝病
疾病
临床试验
病理
药理学
内科学
物理疗法
生物
植物
出处
期刊:PubMed
日期:2023-04-20
卷期号:31 (4): 337-338
标识
DOI:10.3760/cma.j.cn501113-20230419-00176
摘要
As a liver disease with the most complex clinical phenotype, drug-induced liver injury (DILI) poses great challenges in diagnosis and management in clinical practice. Although guidelines based on the latest research advances can provide clinicians with guidance on the identification, diagnosis, and management of DILI, the overall level of evidence in this field is relatively low and high-level evidence is limited. Therefore, we should interpret guidelines with caution and look forward to more clinical and translational research to address the huge unmet clinical needs in DILI.作为临床表型最为复杂的肝脏疾病,药物性肝损伤的临床诊断和管理是实践中的难点。尽管依据最新研究进展而制定指南可为临床医生提供药物性肝损伤识别、诊断和管理的专业指导,但目前本领域的循证医学证据整体还较弱,高级别证据更是有限。因此,我们应深刻理解、正解解读指南,并期待开展更多的临床和转化研究,以解决药物性肝损伤领域目前大量未被满足的临床需求。.
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