微小病毒
蛋白酶
蛋白酵素
复制(统计)
计算生物学
相似性(几何)
化学
病毒学
生物
酶
核糖核酸
计算机科学
生物化学
人工智能
基因
图像(数学)
作者
Li Wan,Xiaobo Wang,Tangle Wang,Xiaolan Yuan,Yan Huang,Wei Liu,Changyong Deng,Shuang Cao
标识
DOI:10.1002/cbdv.202201100
摘要
The 3C protease (3C Pro) plays a significant role in the life cycle of picornaviruses from replication to translation, making it an attractive target for structure-based design of drugs against picornaviruses. The structurally related 3C-like protease (3CL Pro) is an important protein involved in the replication of coronaviruses. With the emergence of COVID-19 and consequent intensive research into 3CL Pro, development of 3CL Pro inhibitors has emerged as a popular topic. This article compares the similarities of the target pockets of various 3C and 3CL Pros from numerous pathogenic viruses. This article also reports several types of 3C Pro inhibitors that are currently undergoing extensive studies and introduces various structural modifications of 3C Pro inhibitors to provide a reference for the development of new and more effective inhibitors of 3C Pro and 3CL Pro.
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