间质细胞
肿瘤微环境
挤压
组织工程
体内
3D生物打印
生物医学工程
材料科学
计算生物学
生物
肿瘤细胞
癌症研究
生物技术
医学
冶金
作者
Salvador Flores-Torres,Tao Jiang,Jacqueline Kort-Mascort,Yun Yang,Omar Peza-Chavez,Sanjima Pal,Alisia Mainolfi,Lucas Antonio Pardo,Lorenzo Ferri,Nicholas Bertos,Veena Sangwan,Joseph M. Kinsella
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2023-01-04
卷期号:9 (2): 542-561
被引量:4
标识
DOI:10.1021/acsbiomaterials.2c00998
摘要
Malignant tumor tissues exhibit inter- and intratumoral heterogeneities, aberrant development, dynamic stromal composition, diverse tissue phenotypes, and cell populations growing within localized mechanical stresses in hypoxic conditions. Experimental tumor models employing engineered systems that isolate and study these complex variables using in vitro techniques are under development as complementary methods to preclinical in vivo models. Here, advances in extrusion bioprinting as an enabling technology to recreate the three-dimensional tumor milieu and its complex heterogeneous characteristics are reviewed. Extrusion bioprinting allows for the deposition of multiple materials, or selected cell types and concentrations, into models based upon physiological features of the tumor. This affords the creation of complex samples with representative extracellular or stromal compositions that replicate the biology of patient tissue. Biomaterial engineering of printable materials that replicate specific features of the tumor microenvironment offer experimental reproducibility, throughput, and physiological relevance compared to animal models. In this review, we describe the potential of extrusion-based bioprinting to recreate the tumor microenvironment within in vitro models.
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