洗剂
痤疮
皮肤病科
医学
化妆品
刺激
皮肤刺激
敏感皮肤
药理学
病理
免疫学
作者
Hongchang Cui,Chaoqun Guo,Qian Wang,Congrui Feng,Zhi Duan
标识
DOI:10.3389/fmed.2022.1064460
摘要
Introduction Acne can compromise facial esthetics and become a mental burden, especially when it occurs in puberty. Skincare cosmetics with anti-acne efficiency is more convenient than other treatment modalities, such as dietary supplements, in certain circumstances. The purpose of this study was to investigate the efficacy of an anti-acne lotion in alleviating acne. Methods In our study, an anti-acne lotion containing ferment lysate produced by Lactiplantibacillus plantarum VHProbi ® E15 were applied to subjects with mild -to -moderate acne over 4 weeks. The efficacy was evaluated based on instrumental measurements using Visia ® -CR and CK-MPA ® system. Results and discussion The anti-acne lotion exhibited favorable safety, meeting the stringent criteria for the detection of microbes, heavy metals, toxicity, and irritation. After 2 weeks of treatment, a statistically significant improvement in acne lesions was observed compared to baseline ( P < 0.01), and this continued to the end of the study. After 4 weeks of treatment, the transepidermal water loss ( P < 0.05) and sebum production ( P < 0.05) were significantly decreased in subjects compared to baseline. In addition, the pore/area of interest (AOI) and stratum corneum hydration displayed slightly positive changes throughout treatment. Thus, we conclude that applying topical anti-acne lotion may be safe and confer effective benefits in people with mild -to -moderate acne and represents a promising therapeutic option for acne.
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