Factors related to non-motor symptoms in moderate to severe parkinson’s disease

Objective: To analyze factors related to non-motor symptoms in patients with moderate to severe Parkinson’s disease. Subjects and Methods: From March 2022 to September 2023, 93 patients with moderate to severe Parkinson’s disease were enrolled in a cross-sectional descriptive study at the Outpatient Department of Bach Mai Hospital. Results: Factors affecting cardiovascular symptoms: Advanced age (≥70 years) and severe disease stage increased the risk of orthostatic hypotension (p < 0.05). Factors affecting sleep disorders (based on NMSS and Epworth scores): Advanced age (≥70 years), disease duration of ≥5 years, and severe disease stage increased the risk of sleep disturbances (p < 0.05). Factors affecting mood disorders (based on NMSS and Geriatric Depression Scale - Short Form scores): Female gender was associated with an increased risk of anxiety and depression. Additionally, a disease duration of ≥5 years and severe disease stage also increased the risk of depression (p < 0.05). Conclusion: Advanced age (≥70 years) and severe disease stage are factors that increase the risk of non-motor symptoms related to cardiovascular function, sleep disorders, and mood disorders.