Advances in the Application of Mass Spectrometry in the Study ofAlkaloid Structure

Abstract: As an efficient analytical method, mass spectrometry can identify the structure of alkaloid compounds, providing important support for drug development and clinical applications. In this manuscript, the basic principles and rules of alkaloid mass spectrometry analysis are reviewed, and the breakage modes and characteristic ions of different types of alkaloids in mass spectrometry are emphatically introduced. By discussing the fragmentation behavior of various alkaloids in negative ion mode and positive ion mode in detail, the mass spectrometry cleavage laws of various alkaloids are revealed, and the application of these laws in practical detection is summarized.