生物
噬菌体疗法
寄主(生物学)
灵活性(工程)
噬菌体展示
计算生物学
噬菌体
遗传学
基因
统计
数学
大肠杆菌
抗体
作者
Ruochen Ouyang,Véronique Ongenae,Alise R. Muok,Dennis Claessen,Ariane Briegel
标识
DOI:10.1016/j.mib.2024.102429
摘要
Bacteriophages are being rediscovered as potent agents for medical and industrial applications. However, finding a suitable phage relies on numerous factors, including host specificity, burst size, and infection cycle. The host range of a phage is, besides phage defense systems, initially determined by the recognition and attachment of receptor-binding proteins (RBPs) to the target receptors of susceptible bacteria. RBPs include tail (or occasionally head) fibers and tailspikes. Owing to the potential flexibility and heterogeneity of these structures, they are often overlooked during structural studies. Recent advances in cryo-electron microscopy studies and computational approaches have begun to unravel their structural and fundamental mechanisms during phage infection. In this review, we discuss the current state of research on different phage tail and head fibers, spike models, and molecular mechanisms. These details may facilitate the manipulation of phage-host specificity, which in turn will have important implications for science and society.
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