高价分子
有机硫化合物
化学
功能群
催化作用
组合化学
基质(水族馆)
硫醇
氧化剂
氧化还原
试剂
有机化学
硫黄
生物
生态学
聚合物
作者
Guangping Sun,Shu‐Zhong Zhan,Yingjie Zhao,Xiangwei Du,Mingying Shi,Jing Li,Haoliang Yuan,Xiaoan Wen,Hongbin Sun,Qing‐Long Xu
标识
DOI:10.1021/acs.joc.3c02175
摘要
A metal-free and thiol-free organophosphorus-catalyzed method for forming thioethers was disclosed, driven by PIII/PV═O redox cycling. In this work, one-step dehydroxylative thioetherification of alcohols was fulfilled with various hypervalent organosulfur compounds. This established strategy features an excellent functional group tolerance and broad substrate scope, especially inactivated alcohols. The scale-up reaction and further transformation of the product were also successful. Additionally, this method offers a protecting-group-free and step-efficient approach for synthesizing peroxisome proliferator-activated receptor agonists which exhibited promising potential for treating osteoporosis in mammals.
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