To close or not to close after colorectal endoscopic submucosal dissection: that is the question!

En bloc resection by endoscopic submucosal dissection (ESD) is increasingly adopted worldwide as the first-line treatment for large (≥20 mm) superficial colorectal neoplasia. Its advantages include complete pathological analysis, the potential to cure selected T1 colorectal cancers, and single-session R0 resection that can obviate the need for early follow-up colonoscopies.