Global prevalence of mental health comorbidity in patients with acne: An analysis of trends from 1961 to 2023

Abstract Background Patients with acne increasingly face mental health challenges such as anxiety, depression and suicidal thoughts. However, no global systematic analysis exists on this topic. Objectives To examine the prevalence of mental disorders – specifically, anxiety, depression and suicidal thoughts – among patients with acne. Methods An exhaustive search of six databases was conducted up to May 2023. Data analysis was performed using Python and Stata MP 17, including subgroup evaluations, metaregression and sensitivity analyses. Results Forty-three studies were analysed. The findings indicate that depression, anxiety and suicidal thoughts in patients with acne are prevalent at rates of 22%, 29% and 12%, respectively. Rates of depression were highest in Asia at 42%, led by India (53%) and Saudi Arabia (51%). Anxiety was also most common in Asia, at 45%, notably in Singapore (60%) and Iran (58%). Suicidal thoughts were highest in Oceania, specifically New Zealand at 24%. The study is limited by the inclusion of only Chinese- and English-language research, potentially introducing selection bias. Conclusions The results of this study highlight the incidence of mental health disorders coexisting with acne. This study may help to foster greater understanding and awareness among both medical professionals and patients regarding the psychological complexities tied to acne.