Efficient and convenient synthesis of methyl (S)-5-chloro-2-hydroxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate: a key intermediate for (S)-indoxacarb using aqueous TBHP as oxidant

The work reports an improved method for the efficient, stereoselective and industrially feasible synthesis of the key intermediate for ( S )-indoxacarb, which features purification by filtration, using aqueous TBHP as an oxidant and mild conditions.