Magnesium-ion-doped silica nanosheets as degradable drug carriers with enhanced antibacterial activity and cellular uptake

concentration was 5 mM, the prepared nanosheets (5MgMSNs) showed superior antibacterial activity and increased curcumin-loading capacity compared to pure silica nanoparticles. Additionally, the natural green fluorescence of curcumin allowed for the visualization of cellular uptake, confirming the efficient internalization of 5MgMSNs by L929 cells. Notably, under acidic conditions, the release of Mg ions and the degradability of the nanoparticles were enhanced, indicating pH-responsive release behavior. Overall, these results highlight the favorable degradability and improved cellular uptake capacity of nanosheet Mg-incorporated silica nanoparticles, suggesting their potential for loading polyphenol drugs such as curcumin and achieving efficient drug release within cells.