瞬态弹性成像
医学
2型糖尿病
脂肪肝
内科学
置信区间
胃肠病学
纤维化
队列
糖尿病
前瞻性队列研究
肝病
疾病
肝纤维化
内分泌学
作者
Seung Min Chung,Min Kyu Kang,Jun Sung Moon,Jung Gil Park
标识
DOI:10.3803/enm.2022.1635
摘要
This cross-sectional study enrolled 267 patients with metabolic risk factors and established non-alcoholic fatty liver disease in the prospective cohort. The performance of fibrosis-4 (FIB-4) score (≥1.3) to diagnose advanced fibrosis using transient elastography (liver stiffness measurement [LSM] ≥8 kPa) was analyzed. Comparing patients with type 2 diabetes (T2D, <i>n</i>=87) and without (<i>n</i>=180), not FIB-4, but LSM was significantly higher in T2D (<i>P</i>=0.026). The prevalence of advanced fibrosis was 17.2% in T2D and 12.8% in non-T2D. FIB-4 exhibited higher proportion of false negatives in T2D patients (10.9%) than those without (5.2%). The diagnostic performance of FIB-4 was suboptimal in T2D (area under curve [AUC], 0.653; 95% confidence interval [CI], 0.462 to 0.844) compared to that in non-T2D (AUC, 0.826; 95% CI, 0.724 to 0.927). In conclusion, patients with T2D might be beneficial to conduct transient elastography without screening to avoid missing advanced fibrosis.
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