化学
分子内力
选择性
立体化学
戒指(化学)
分子
组合化学
有机化学
催化作用
作者
Bhaskar Chatterjee,Dhananjoy Mondal,Smritilekha Bera
标识
DOI:10.1002/ajoc.202200702
摘要
Abstract dinoflagellates amphidinolide group of natural products have drawn the attention of the synthetic community owing to their natural scarcity, variation in ring size (12‐ to 27‐membered), and architectural complexity. The manifold strategies for creating the unique macrocyclic framework of amphidinolides, overcoming the entropy barrier of cyclisation, in good yields and selectivity, are highly encouraging as this platform provides an opportunity to develop compounds for structure‐activity relationship studies. This review emphasizes various methods of intramolecular C−C and C−O bond‐forming reactions for constructing the macrocyclic structure of different naturally occurring molecules of amphidinolide family.
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