巨噬细胞极化
炎症
极化(电化学)
化学
天然化合物
生物
巨噬细胞
生物化学
免疫学
体外
生化工程
工程类
物理化学
作者
Zhen Chang,Youhan Wang,Chang Liu,Wanli W. Smith,Lingbo Kong
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2020-10-14
卷期号:15 (7): 559-569
被引量:9
标识
DOI:10.2174/1574888x14666190523093535
摘要
Macrophages M2 polarization have been taken as an anti-inflammatory progression during inflammation. Natural plant-derived products, with potential therapeutic and preventive activities against inflammatory diseases, have received increasing attention in recent years because of their whole regulative effects and specific pharmacological activities. However, the molecular mechanisms about how different kinds of natural compounds regulate macrophages polarization still unclear. Therefore, in the current review, we summarized the detailed research progress on the active compounds derived from herbal plants with regulating effects on macrophages, especially M2 polarization. These natural occurring compounds including flavonoids, terpenoids, glycosides, lignans, coumarins, alkaloids, polyphenols and quinones. In addition, we extensively discussed the cellular mechanisms underlying the M2 polarization for each compound, which could provide potential therapeutic strategies aiming macrophages M2 polarization.
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