胃肠病学
优势比
内科学
癌症
次等位基因频率
幽门螺杆菌
萎缩性胃炎
萎缩
医学
单核苷酸多态性
等位基因
病例对照研究
癌变
人口
病理
基因型
胃炎
生物
遗传学
基因
环境卫生
作者
Jing Wu,Toshimi Otsuka,Masakatsu Nakamura,Naoki Sakurai,Hikaru Takano,Tetsuya Hayashi,Masafumi Ota,Tomoe Nomura,Ranji Hayashi,Takeo Shimasaki,Tomomitsu Tahara,Tomoyuki Shibata,Tomiyasu Arisawa
出处
期刊:Oncology Letters
[Spandidos Publications]
日期:2019-01-18
被引量:1
摘要
The aim of the present study was to investigate whether single nucleotide polymorphisms in the DNMT3A gene are associated with susceptibility to gastric cancer in the Japanese population. The present case‑control study examined the associations between single nucleotide polymorphisms (rs6733868 and rs13428812) in DNMT3A and cancer susceptibility in 343 patients with gastric cancer and 708 subjects without gastric malignancies on upper gastro‑duodenal endoscopy. Of 708 controls, 409 were classified into two groups histologically: 99 cases with and 310 cases without gastric mucosal atrophy. Overall, homozygosity for the DNMT3A rs6733868 minor allele was significantly associated with a reduced risk of gastric cancer (odds ratio [OR], 0.621; 95% confidence interval [CI], 0.402‑0.958; P=0.031), especially of the intestinal type (OR, 0.494; 95% CI, 0.274‑0.890; P=0.019). In subjects >60 years, rs6733868 minor allele homozygosity was significantly associated with gastric cancer susceptibility. Carriers of the rs6733868 minor allele had a reduced risk of severe gastric mucosal atrophy (OR, 0.495; 95% CI, 0.299‑0.826; P=0.0069). In addition, the number of minor alleles of both rs6733868 and rs13428812 was significantly correlated with the risk of Helicobacter pylori (HP) infection (P=0.0070 and P=0.0050, respectively). However, rs13428812 was not associated with severe gastric mucosal atrophy or gastric carcinogenesis. The present results suggest that DNMT3A polymorphisms serve roles in the progression from HP infection to gastric mucosal atrophy and gastric carcinogenesis in terms of degree and manner.
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