Comment on the letter to editor: Closed loop stimulation for tremor was invented in 1980

We thank Professors Blomstedt and Hariz for drawing our attention to the pioneering work of Brice and McLellan on tremor in multiple sclerosis [ [1] Brice J. McLellan L. Suppression of intention tremor by contingent deep brain stimulation. Lancet. 1980; 1: 1221e2 Google Scholar ]. These authors were the first to realise and demonstrate the potential of closed-loop control in Deep Brain Stimulation. Such control adjusts stimulation parameters in real-time based on continuous feedback input signals that reflect the patient's fluctuating clinical state, and has the potential to increase the therapeutic window available to patient and clinician.