医学
鼓膜穿孔
穿孔
成纤维细胞
成纤维细胞生长因子
碱性成纤维细胞生长因子
伤口愈合
再生(生物学)
外科
生长因子
内科学
鼓室成形术
体外
细胞生物学
生物化学
生物
冲孔
材料科学
冶金
受体
作者
Lou Zc,Lou Zh,Jian Xiao
出处
期刊:Journal of Laryngology and Otology
[Cambridge University Press]
日期:2018-06-01
卷期号:132 (06): 470-478
被引量:16
标识
DOI:10.1017/s002221511800083x
摘要
Abstract Objective A systematic review was conducted to investigate the effectiveness of fibroblast growth factor-2 on the regeneration of tympanic membrane perforation. Methods The PubMed database was searched for relevant studies. Experimental studies, human randomised controlled trials, prospective single-arm studies and retrospective studies reporting acute and chronic tympanic membrane perforations in relation to two healing outcomes (success rate and closure time), were selected. Results All 11 clinical studies investigating the effect of fibroblast growth factor-2 on traumatic tympanic membrane perforations in humans reported a success rate of 89.3–100 per cent, with a closure time of around 2 weeks. Three studies of fibroblast growth factor-2 combined with Gelfoam showed that the success rate of chronic tympanic membrane perforation was 83–98.1 per cent in the fibroblast growth factor-2 group, but 10 per cent in the gelatine sponge groups. Conclusion Fibroblast growth factor-2 with or without biological material patching promotes regeneration in cases of acute and chronic tympanic membrane perforation, and is safe and efficient. However, the best dosage, application time and administration pathway of fibroblast growth factor-2 are still to be elucidated.
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