生物相容性
纳米复合材料
聚氨酯
光催化
材料科学
抗菌活性
单线态氧
纳米技术
核化学
复合材料
氧气
化学
催化作用
有机化学
细菌
生物
冶金
遗传学
作者
Mária Kováčová,Zoran M. Marković,Petr Humpolíček,Matej Mičušík,Helena Švajdlenková,Angela Kleinová,Martin Danko,Pavel Kubát,Jan Vajďák,Zdenka Capáková,Marián Lehocký,Lukáš Münster,Biljana M. Todorović Marković,Zdeno Špitalský
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2018-09-27
卷期号:4 (12): 3983-3993
被引量:112
标识
DOI:10.1021/acsbiomaterials.8b00582
摘要
Development of new types of antibacterial coatings or nanocomposites is of great importance due to widespread multidrug-resistant infections including bacterial infections. Herein, we investigated biocompatibility as well as structural, photocatalytic, and antibacterial properties of photoactive hydrophobic carbon quantum dots/polyurethane nanocomposite. The swell-encapsulation-shrink method was applied for production of these nanocomposites. Hydrophobic carbon quantum dots/polyurethane nanocomposites were found to be highly effective generator of singlet oxygen upon irradiation by low-power blue light. Analysis of conducted antibacterial tests on Staphyloccocus aureus and Escherichia coli showed 5-log bactericidal effect of these nanocomposites within 60 min of irradiation. Very powerful degradation of dye (rose bengal) was observed within 180 min of blue light irradiation of the nanocomposites. Biocompatibility studies revealed that nanocomposites were not cytotoxic against mouse embryonic fibroblast cell line, whereas they showed moderate cytotoxicity toward adenocarcinomic human epithelial cell line. Minor hemolytic effect of these nanocomposites toward red blood cells was revealed.
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