溶解度
化学
非随机双液模型
溶解
焓
盐酸利多卡因
重量分析
吉布斯自由能
乙酸乙酯
热力学
溶剂
丙酮
色谱法
有机化学
活度系数
水溶液
利多卡因
麻醉
物理
医学
作者
Guangyi Zhou,Jiejie Dong,Zhirong Wang,Zhili Li,Qunsheng Li,Baohua Wang
标识
DOI:10.1016/j.molliq.2018.06.035
摘要
The objective of this work was to measure and correlate the solubility of lidocaine hydrochloride in eight pure solvents, including ethanol, n-propanol, isopropanol, n-butanol, isobutanol, acetone, methyl acetate, water, and binary mixtures at (291.15 to 331.15) K by using gravimetric method under atmospheric pressure. The results reveal that the solubility of lidocaine hydrochloride increases with increasing temperature in all solvent selected. The modified Apelblat equation, van’t Hoff equation, λh equation, Wilson model and NRTL model were successfully used to correlate the experimental solubility in pure solvents and binary solvent mixtures. In addition, the thermodynamic properties of dissolution of Lidocaine hydrochloride such as Gibbs energy (∆G°sol), molar enthalpy of dissolution (∆H°sol), and molar entropy of dissolution (∆S°sol ) were calculated. Consequently, the experimental solubility and correlation equations can be used as essential data and simulation models in the purification and separation of lidocaine hydrochloride.
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