拉曼散射
纳米技术
计算机科学
灵敏度(控制系统)
领域(数学)
材料科学
分析物
拉曼光谱
化学
电子工程
工程类
物理
光学
数学
物理化学
纯数学
作者
Roberto Pilot,Raffaella Signorini,Christian Durante,Laura Orian,Manjari Bhamidipati,Laura Fabris
出处
期刊:Biosensors
[MDPI AG]
日期:2019-04-17
卷期号:9 (2): 57-57
被引量:541
摘要
Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field.
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