生物相容性
单线态氧
铱
磷光
光敏剂
光动力疗法
化学
纳米颗粒
光化学
量子产额
细胞毒性
纳米技术
生物相容性材料
荧光
组合化学
材料科学
体外
氧气
催化作用
有机化学
生物医学工程
生物化学
物理
医学
量子力学
作者
Liping Zhang,Yuanyuan Li,Weilong Che,Dongxia Zhu,Guangfu Li,Zhigang Xie,Nan Song,Lei Shi,Ben Zhong Tang,Xingman Liu,Zhong‐Min Su,Martin R. Bryce
标识
DOI:10.1002/advs.201802050
摘要
Abstract The singlet oxygen ( 1 O 2 ) generation ability of a photosensitizer (PS) is pivotal for photodynamic therapy (PDT). Transition metal complexes are effective PSs, owing to their high 1 O 2 generation ability. However, non‐negligible cellular toxicity, poor biocompatibility, and easy aggregation in water limit their biomedical applications. In this work, a series of red‐emitting aggregation‐induced emission (AIE) Ir(III) complexes containing different numbers of Ir centers (mono‐, di‐, and trinuclear) and the corresponding nanoparticles (NPs) AIE‐NPs, are designed and synthesized. The increase of 1 O 2 generation ability is in line with the increasing number of Ir centers. Compared with the pure Ir(III) complexes, the corresponding NPs offer multiple advantages: (i) brighter emission; (ii) higher phosphorescence quantum yields; (iii) longer excited lifetime; (iv) higher 1 O 2 generation ability; (v) better biocompatibility; and (vi) superior cellular uptake. Both in vitro and in vivo experiments corroborate that AIE‐NPs with three iridium centers possess potent cytotoxicity toward cancer cells and effective inhibition of tumor growth. To the best of knowledge, this work is the first example of NPs of multinuclear AIE Ir(III) complexes as PSs for enhanced PDT. This study offers a new method to improve the efficiency of PSs for clinical cancer treatments.
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