Natural biodegradable polymers based nano-formulations for drug delivery: A review

Abstract Nanomedicines are now considered as the new-generation medication in the current era mainly because of their features related to nano size. The efficacy of many drugs in their micro/macro formulations is shown to have poor bioavailability and pharmacokinetics after oral administration. To overcome this predicament, use of natural/synthetic biodegradable polymeric nanoparticles (NPs) have gained prominence in the field of nanomedicine for targeted drug delivery to improve biocompatibility, bioavailability, safety, enhanced permeability, better retention time and lower toxicity. For drug delivery, it is essential to have biodegradable nanoparticle formulations for safe and efficient transport and release of drug at the intended site. Moreover, depending on the target organ, a suitable biodegradable polymer can be selected as the drug-carrier for target specific as well as for sustained drug delivery. The aim of this review is to present the current status and scope of natural biodegradable polymers as well as some emerging polymers with special characteristics as suitable carriers for drug delivery applications. The most widely preferred preparation methods are discussed along with their characterization using different analytical techniques. Further, the review highlights significant features of methods developed using natural polymers for drug entrapment and release studies.