人工智能
计算机科学
分割
推论
深度学习
模式识别(心理学)
结肠镜检查
图像分割
源代码
机器学习
结直肠癌
癌症
医学
操作系统
内科学
作者
Ruiwei Feng,Xuechen Liu,Jintai Chen,Danny Z. Chen,Honghao Gao,Jian Wu
出处
期刊:IEEE Journal of Biomedical and Health Informatics
[Institute of Electrical and Electronics Engineers]
日期:2021-10-01
卷期号:25 (10): 3700-3708
被引量:66
标识
DOI:10.1109/jbhi.2020.3040269
摘要
Colorectal cancer (CRC) is one of the most life-threatening malignancies. Colonoscopy pathology examination can identify cells of early-stage colon tumors in small tissue image slices. But, such examination is time-consuming and exhausting on high resolution images. In this paper, we present a new framework for colonoscopy pathology whole slide image (WSI) analysis, including lesion segmentation and tissue diagnosis. Our framework contains an improved U-shape network with a VGG net as backbone, and two schemes for training and inference, respectively (the training scheme and inference scheme). Based on the characteristics of colonoscopy pathology WSI, we introduce a specific sampling strategy for sample selection and a transfer learning strategy for model training in our training scheme. Besides, we propose a specific loss function, class-wise DSC loss, to train the segmentation network. In our inference scheme, we apply a sliding-window based sampling strategy for patch generation and diploid ensemble (data ensemble and model ensemble) for the final prediction. We use the predicted segmentation mask to generate the classification probability for the likelihood of WSI being malignant. To our best knowledge, DigestPath 2019 is the first challenge and the first public dataset available on colonoscopy tissue screening and segmentation, and our proposed framework yields good performance on this dataset. Our new framework achieved a DSC of 0.7789 and AUC of 1 on the online test dataset, and we won the [Formula: see text] place in the DigestPath 2019 Challenge (task 2). Our code is available at https://github.com/bhfs9999/colonoscopy_tissue_screen_and_segmentation.
科研通智能强力驱动
Strongly Powered by AbleSci AI