斑马鱼
食欲
5-羟色胺能
下丘脑
神经科学
外侧下丘脑
生物
刺激
食物摄入量
感觉系统
内科学
摄食行为
内分泌学
医学
血清素
受体
遗传学
基因
作者
Caroline Lei Wee,Erin Song,Robert E. Johnson,Deepak Ailani,Owen Randlett,Ji-Yoon Kim,Maxim Nikitchenko,Armin Bahl,Chao-Tsung Yang,Misha B. Ahrens,Koichi Kawakami,Florian Engert,Sam Kunes
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2019-10-18
卷期号:8
被引量:45
摘要
Medial and lateral hypothalamic loci are known to suppress and enhance appetite, respectively, but the dynamics and functional significance of their interaction have yet to be explored. Here we report that, in larval zebrafish, primarily serotonergic neurons of the ventromedial caudal hypothalamus (cH) become increasingly active during food deprivation, whereas activity in the lateral hypothalamus (LH) is reduced. Exposure to food sensory and consummatory cues reverses the activity patterns of these two nuclei, consistent with their representation of opposing internal hunger states. Baseline activity is restored as food-deprived animals return to satiety via voracious feeding. The antagonistic relationship and functional importance of cH and LH activity patterns were confirmed by targeted stimulation and ablation of cH neurons. Collectively, the data allow us to propose a model in which these hypothalamic nuclei regulate different phases of hunger and satiety and coordinate energy balance via antagonistic control of distinct behavioral outputs.
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