Immune-mediated necrotizing myopathies and interstitial lung disease are predominant characteristics in anti-Ku positive patients with idiopathic inflammatory myopathies

Correspondence patients, respectively.In addition, 1 patient with coexistence of anti-Ku and anti-Jo-1 was diagnosed with non-specific myositis according to the 2004 ENMC classification criteria for IIM(table 1, figure 1). 7n conclusion, the presence of anti-Ku autoantibodies is rare among IIM patients.Concomitant ILD and elevated CK level are common features of anti-Ku positive patients.However, the clinical and pathological characteristics are distinct in patients with isolated anti-Ku and those with coexistence of anti-Ku and MSA.Skin rash is more common in patients with coexistence of anti-Ku and MSA, while severe ILD and IMNM are common in patients with isolated anti-Ku.Further studies on the characteristics of anti-Ku-positive IIM using larger cohorts are warranted.