溶瘤病毒
医学
溶癌病毒
胶质母细胞瘤
胶质瘤
替莫唑胺
癌症研究
单纯疱疹病毒
肿瘤科
放射治疗
脑瘤
化疗
间变性星形细胞瘤
病毒
免疫学
肿瘤细胞
作者
Dagoberto Estevez-Ordonez,Gustavo Chagoya,Arsalaan Salehani,Travis J. Atchley,Nicholas M B Laskay,Matthew S. Parr,Galal A. Elsayed,Anil K. Mahavadi,Sage P. Rahm,Gregory K. Friedman,James M. Markert
标识
DOI:10.1016/j.nec.2020.12.008
摘要
Glioblastoma multiforme (GBM) represents one of the most challenging malignancies due to many factors including invasiveness, heterogeneity, and an immunosuppressive microenvironment. Current treatment modalities have resulted in only modest effect on outcomes. The development of viral vectors for oncolytic immunovirotherapy and targeted drug delivery represents a promising therapeutic prospect for GBM and other brain tumors. A host of genetically engineered viruses, herpes simplex virus, poliovirus, measles, and others, have been described and are at various stages of clinical development. Herein we provide a review of the advances and current state of oncolytic virotherapy for the targeted treatment of GBM and malignant gliomas.
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