谷氨酰胺分解
谷氨酰胺酶
谷氨酰胺
酶
生物
细胞生物学
癌症研究
糖酵解
医学
生物信息学
生物化学
氨基酸
作者
Yoshikazu Johmura,Takehiro Yamanaka,Satotaka Omori,Teh Wei Wang,Yuki Sugiura,Masaki Matsumoto,Shosaku Narumi,Soichiro Kumamoto,Kiyoshi Yamaguchi,Seira Hatakeyama,Tomoyo Takami,Rui Yamaguchi,Eigo Shimizu,Kazutaka Ikeda,Nobuyuki Okahashi,Ryuta Mikawa,Makoto Suematsu,Makoto Arita,Masataka Sugimoto,Keiichi I. Nakayama,Yoichi Furukawa,Seiya Imoto,Makoto Nakanishi
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-01-15
卷期号:371 (6526): 265-270
被引量:206
标识
DOI:10.1126/science.abb5916
摘要
Selective destruction of senescent cells Senescent cells are associated with a variety of age-related medical conditions and thus have been proposed as potential targets for therapy, but we do not yet have a full understanding of the underlying mechanisms. Johmura et al. used RNA interference to screen for enzymes essential to the survival of senescent cells (see the Perspective by Pan and Locasale). The authors identified a key role for glutamine metabolism, particularly the enzyme glutaminase 1, and demonstrated that inhibition of this pathway induced the death of senescent cells. Glutaminase targeting also ameliorated aging-related organ dysfunction and obesity-related disorders in mouse models, suggesting the potential therapeutic value of this approach. Science , this issue p. 265 ; see also p. 234
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