化学
烯烃
电泳剂
试剂
催化作用
组合化学
钯
四级碳
对映选择合成
有机化学
立体化学
作者
Min Liu,Xing Wang,Ziqiong Guo,Hanyuan Li,Wei Huang,Hui Xu,Hui‐Xiong Dai
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-08-05
卷期号:23 (16): 6299-6304
被引量:12
标识
DOI:10.1021/acs.orglett.1c02093
摘要
Herein, we report the palladium-catalyzed asymmetric acyl-carbamoylation of an alkene by employing thioesters as the acyl electrophiles and t-BuNC as the carbamoyl reagent, affording an α-quaternary chiral cycloketone in synthetically useful yields with excellent enantioselectivity. The reaction proceeded via asymmetric 1,2-migratory insertions of acyl-Pd into alkenes and subsequent migratory insertion of isocyanides into C(sp3)–PdII. The product could be diversified to some valuable skeletons with retention of enantiopurity, demonstrating the synthetic utility of this protocol.
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