细胞生物学
表观遗传学
胞浆
乙酰化
线粒体DNA
间充质干细胞
生物
细胞器
组蛋白
DNA甲基化
化学
线粒体
计算生物学
染色质
遗传学
生物化学
基因
酶
作者
Carina Groh,Johannes M. Herrmann
出处
期刊:Nature Aging
日期:2021-09-01
标识
DOI:10.1038/s43587-021-00111-w
摘要
New research reveals that the mitochondrial citrate carrier is crucial for the accumulation of acetyl-CoA in the cytosol and nucleus, and efficient histone acetylation. Lysosomal degradation of this carrier drives mesenchymal stem cell aging in a process characterized by tightly packed chromatin and reduced expression of osteogenic genes.
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