Synthesis of Indole-Fused Six-, Seven-, or Eight-Membered N,O-Heterocycles via Rhodium-Catalyzed NH-Indole-Directed C–H Acetoxylation/Hydrolysis/Annulation

We report herein the facile synthesis of indole-fused six-, seven-, or eight-membered N,O-heterocycles through rhodium-catalyzed C–H acetoxylation/hydrolysis/annulation. The notable features of this method include C–H acetoxylation using NH -indole as the intrinsic directing group, high functional group compatibility, and construction of indole-fused medium-sized rings.