Fabrication of the biomimetic DOX/Au@Pt nanoparticles hybrid nanostructures for the combinational chemo/photothermal cancer therapy

The emergence of the biomimetic nano-drug delivery system provides a feasible way for the clinical treatment of cancer. Noble metal nanomaterials often possess unique and intriguing physicochemical properties, optical properties, electromagnetic properties and catalytic properties, therefore have broad applications in the field of biomedicine. In this work, the porous [email protected] bimetallic nanoparticles were synthesized via the blending of the chloroauric acid (a gold precursor) with the potassium chloroplatinate (a platinum precursor) at the ratio of 1:1. These [email protected] NPs exhibited decent catalytic properties, high drug loading capacity (32.3%) and high photothermal conversion efficiency (44.1%). Based on the resultant [email protected] NPs, a cell membrane-coated photothermal nano-drug delivery system (i.e. the DOX/[email protected]) was formulated by loading the Doxorubicin (DOX) onto the [email protected] nanoparticles, which showed a stronger inhibitory effect on tumor cells. The use of the HeLa tumor cell membrane coating demonstrated significantly reinforcing effect on the absorption of the DOX/[email protected] by tumor cells because of homologous targeting. The cytotoxicity and apoptosis rate of the DOX/[email protected] group (73.4%) were significantly higher than that of the [email protected] group (49%). In addition, the damage to major organs caused by the DOX/[email protected] nanoparticle group was significantly lower than that by the DOX/[email protected] nanoparticle group and the pure DOX group. Taken together, our work demonstrated that nanomedicine carriers camouflaged by tumor cell membranes combined with photothermal therapy and chemotherapy would have potential use in clinical tumor treatment.