Chloramine-T in Organic Synthesis and Analysis of Organic Functional Groups: A Review

The diverse nature of Chloramine-T, the sodium salt of N-chloro-p-toluenesulfonamide, abbreviated as CAT, acts as a source of halonium cation and nitrogen anion, and acts as both base and nucleophile. It reacts with broad range of functional groups and brings divergent molecular transformations to synthetic chemistry. CAT has also gained much recognition as a mild oxidant for several organic moieties and has been used as a versatile reagent for the estimation of various functional groups in analytical chemistry. This review relays the synthetic and analytic utility of CAT from different literature sources. As aspects of the synthetic utility of CAT have not previously been reviewed, this article gives a comprehensive profile of the CAT reagent for further research development.