The effect of intradermal injection of collagenase in implanted hypertrophic scar in nude mice

Objective Effects of collagen degradation in hypertrophic scar by intradermal injection of collagenase were observed.Methods Hypertrophic scar was implanted into nude mice and collagenase was injected locally.Light and electron microscopic observations were carried out.Results Collagen degradation in hypertrophic scar by intradermal injecton of collagenase was observed.The implanted scars became soft,thin and small.Conclusion These results suggested that local injection of collagenase may be a useful therapeutic tool for hypertrophic scar.