毛螺菌科
间歇性禁食
微生物群
肠道菌群
肠道微生物群
生理学
梭菌目
生物
肥胖
医学
内科学
失调
内分泌学
生物信息学
免疫学
细菌
梭菌
遗传学
厚壁菌
16S核糖体RNA
作者
Jasmine W. Larrick,Andrew R Mendelsohn,James W Larrick
标识
DOI:10.1089/rej.2021.0025
摘要
Intermittent fasting (IF) is the practice of restricting food intake for 12–48 hours per fasting cycle over a prolonged period of time. Previous study shows beneficial health effects such as weight loss and lower risk for cardiometabolic diseases. Although reduced calorie intake may account for some of the observed benefits of IF, exact mechanisms are still unclear. Recent evidence indicates that IF may lead to remodeling and increased taxonomic diversity in the human gut microbiome. In particular, the Lachnospiraceae family of anaerobic bacteria increased during fasting. This family, in the order Clostridiales, promotes butryogenesis in the gut, a process that is associated with healthful metabolic and prolongevity effects. IF-associated alterations to the microbiome may play a key role in the metabolic and potential healthspan-enhancing benefits of IF and dietary restriction.
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