医学
单纯疱疹病毒
疾病
聚合酶链反应
HSL和HSV色彩空间
病毒学
儿科
免疫学
病毒
重症监护医学
病理
生物
生物化学
基因
作者
Nicole L. Samies,Scott H. James,David W. Kimberlin
标识
DOI:10.1016/j.clp.2021.03.003
摘要
This article defines neonatal herpes simplex virus (HSV) disease and describes the progress over the past 40 years that has revolutionized the management of HSV disease in neonates to improve their outcomes. These advancements include the introduction of acyclovir in the 1980s, polymerase chain reaction (PCR) for the detection of HSV DNA in the 1990s, and recommendations on managing infants born to mothers with active genital lesions. Despite these advancements, however, there remain high morbidity and mortality in affected neonates, with need for continued improvement. Areas of high interest include vaccine development and rapid PCR detection at time of delivery.
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