Catalytic Asymmetric Construction of a 1,2,4-Benzotriazepine Skeleton via Diastereo- and Enantioselective Decarboxylative [4 + 3] Cyclization.
组合化学
作者
Yanfeng Gao,Xuange Zhang,Xiyuan Zhang,Zhiwei Miao
出处
期刊:Organic Letters [American Chemical Society] 日期:2021-03-12卷期号:23 (7): 2415-2420被引量:2
标识
DOI:10.1021/acs.orglett.1c00073
摘要
We have developed a protocol for palladium-catalyzed decarboxylative [4 + 3] cycloaddition reactions between 4-vinyl benzoxazinanones and azomethine imines to generate moderate to good yields of structurally diverse 1,2,4-benzotriazepines bearing two stereogenic centers with good to excellent stereoselectivities. This protocol not only addresses the challenge of asymmetrically constructing compounds with a 1,2,4-benzotriazepine skeleton but also demonstrates the utility of decarboxylative cycloadditions for the synthesis of enantioenriched polycyclic compounds.